Article

Ectopic hepatocyte transplantation cures the pig model of tyrosinemia

2019-05-29

Abstract excerpt

The effectiveness of cell-based therapies to treat liver failure is limited by the diseased liver environment. Herein we provide preclinical proof-of-concept for the treatment of liver failure through hepatocyte transplantation into lymph nodes in a large-animal model of hereditary tyrosinemia type 1 (HT1), a metabolic liver disease caused by deficiency of fumarylacetoacetate hydrolase (FAH) enzyme. FAH-deficient...

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Literature Corpus work: 5fa94c22-814a-5ce8-a8a1-c5632f8cd471
DOI: 10.1101/648493

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