Unravelling the Barriers: Current Limitations in Cancer Biology Research and How to Overcome Them

Abstract excerpt

- Cancer research faces significant biological, technological, and systemic limitations that hinder the development of effective therapies and improved patient outcomes. Traditional preclinical models such as 2D and 3D cell cultures, murine xenografts, and organoids, often fail to reflect the complexity of human tumor architecture, microenvironment, and immune interactions. This disconnects results in promising la...

Topics

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• Cancer Cells and Metastasis
• Cancer Genomics and Diagnostics
• Cancer Mechanisms and Therapy
• Clonal Evolution
• Disease Management
• Histone Deacetylase Inhibitors Research
• Immune cells in cancer
• Single-cell and spatial transcriptomics

Identifiers and source

Literature Corpus work

5f56c7f3-1330-52f1-91ea-7afe3301e6c1

DOI

10.20944/preprints202505.1837.v1