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A Locus Control Region Generates Distinct Active Placental Lactogen And Inactive Growth Hormone Gene Domains In Term Placenta That Are Disrupted With Obesity

2024-12-20

Abstract excerpt

A Placental villi include an outer layer of syncytiotrophoblasts (STBs) and an inner layer of cytotrophoblasts (CTBs) that fuse to generate STBs in pregnancy. While activation of the single locus containing the human (h) placental lactogen (hPL) genes ( hPL-A / CSH1 and hPL-B / CSH2 ) begins in the CTBs, their expression in STBs requires further epigenetic modifications as well as interactions between lo...

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Literature Corpus work: 5f1d4825-2abc-57e2-bfd8-f1ed4a272a73
DOI: 10.1101/2024.12.18.628357

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