Article

Pure large cell neuroendocrine carcinoma of the ovary with a somatic BRCA1 mutation: the first reported case and the review of the literature

2023-07-18

Abstract excerpt

Pure large cell neuroendocrine carcinomas (pLCNEC) of the ovary are extremely rare, so there is a lack of molecular information on this type of cancer. Herein, we presented a pure primary LCNEC of the ovary with a pathogenic somatic mutation at the c.5332 + 1g > a splice site of the BRCA1 gene. To the best of our knowledge, this is the first report of a BRCA1 somatic mutation found in the ovary LCNEC. Testing BRCA...

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Literature Corpus work: 5eee18d4-39c4-5455-8d38-a4ad413956d9
DOI: 10.21203/rs.3.rs-3129750/v1

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