Article
BRAF V600E-mutated large cell neuroendocrine carcinoma responding to targeted therapy: a case report and review of the literature.
Anti-cancer drugs - 1 Nov 2023
Ricco Gianluca, Seminerio Renata, Andrini Elisa, Malvi Deborah, Gruppioni Elisa, Altimari Annalisa, Zagnoni Stefano, Campana Davide, Lamberti Giuseppe
Abstract excerpt
Large cell neuroendocrine carcinoma (LCNEC) is a rare and aggressive high-grade neuroendocrine tumor, commonly arising in the lung or in the gastrointestinal tract, with a frequent proportion of unknown primary origin (20%). In the metastatic setting, platinum-based or fluoropyrimidine-based chemotherapeutic regimens are as considered the first-line treatment, despite the limited duration of response. To date,...
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