Article

Hypoxia drives the formation of lung micropapillary adenocarcinoma through hypoxia-inducible factor-1α

2024-06-27

Abstract excerpt

<title>Abstract</title> <p>Micropapillary adenocarcinoma (MPC) is an aggressive histologic subtype of lung adenocarcinoma (LUAD). MPC is composed of small clusters of cancer cells exhibiting inverted polarity. However, the mechanism underlying its formation is poorly understood. Here we show that hypoxia is involved in MPC formation. Spatial transcriptome (ST) analysis with human LUAD tissue suggested that hypoxi...

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Literature Corpus work: 5ec3fad8-a2e3-5c5a-a02f-e75a3013dc7c
DOI: 10.21203/rs.3.rs-4508444/v1

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