Article

Bone morphogenetic proteins 9 & 10 in pulmonary arterial hypertension

2019-01-01

Abstract excerpt

Pulmonary arterial hypertension (PAH) is a rare disease initiated by dysfunction of the pulmonary vascular endothelium. Mutations in BMPR2, which encodes the type-II bone morphogenic protein (BMP) receptor BMPR-II, explain the majority of heritable PAH. BMPR-II forms a signalling complex, with ALK1 and endoglin, specific to endothelial cells which maintains vascular quiescence. BMP9 and BMP10 are the high affinity...

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Literature Corpus work: 5dc9d8c1-9f31-5de4-afaa-cedd7afe5b2d
DOI: 10.17863/cam.53745

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