Article

Hypoxia/HIF Signaling Negatively Regulates Bone Marrow Adiposity after Radiation Exposure

2025-09-08

Abstract excerpt

<h4>ABSTRACT</h4> Radiation therapy is an essential cancer treatment, yet collateral damage to normal tissues remains a major clinical challenge. In bone, radiation-induced toxicity is characterized by loss of hematopoietic function, reduced bone volume, and increased marrow adipose tissue (MAT). Importantly, cancer patients who undergo radiotherapy exhibit significantly higher fracture risk compared to those rec...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 5dc7cd14-7649-506b-9610-45d0e11d022e
DOI: 10.1101/2025.09.07.674016

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Hypoxia/HIF Signaling Negatively Regulates Bone Marrow Adiposity after Radiation ExposureDOI 10.1101/2025.09.07.674016Read

Differential impact of FLASH and conventional radiotherapy on a pivotal metabolic organ: White Adipose TissueSemantic proximity Read

Bone Marrow Adiposity in Models of Radiation- and Aging-Related Bone Loss Is Dependent on Cellular SenescenceSemantic proximity Read

Molecular Deconvolution of Bone Marrow Adipose Tissue Interactions with Malignant Hematopoiesis: Potential for New Therapy DevelopmentSemantic proximity Read

Adipose tissue sensitivity to radiation exposure.Semantic proximity Read

Reprogrammed marrow adipocytes contribute to myeloma-induced bone diseaseSemantic proximity Read

A novel skeletal-specific adipogenesis pathway defines key origins and adaptations of bone marrow adipocytes with age and diseaseSemantic proximity Read

Radiation induces long-term muscle fibrosis and promotes a fibrotic phenotype in fibro-adipogenic progenitors.Semantic proximity Read

Bone marrow adipose tissue is a unique adipose subtype with distinct roles in systemic glucose homeostasisSemantic proximity Read

High-Fat Diet and Altered Radiation ResponseSemantic proximity Read

Adipocytes in hematopoiesis and acute leukemia: friends, enemies, or innocent bystanders?Semantic proximity Read

Ionizing Radiation Activates Mitochondrial Function in Osteoclasts and Causes Bone Loss in Young Adult Male MiceSemantic proximity Read

Bone marrow adipocytes promote the regeneration of stem cells and haematopoiesis by secreting SCF.Semantic proximity Read