Article

Probiotic-conditioned microbiota from preterm infants modulate immune response to pathogen challenge in a humanized mouse model

2025-12-10

Abstract excerpt

Early-life host-microbe interactions critically shape immune development, lifelong homeostasis, and disease susceptibility. The PRIMAL trial (Priming Immunity at the Beginning of Life) demonstrated that multistrain probiotics shifted the gut microbiota of very preterm infants toward eubiosis without affecting sepsis incidence, yet the immunological consequences remained unresolved. To explore this, we colonized ge...

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Literature Corpus work: 5d9f3122-4951-5b06-ae73-6235096d789d
DOI: 10.64898/2025.12.08.692141

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