Evaluation of antibacterial activities of colistin, rifampicin and meropenem combinations against NDM-1-producing<i>Klebsiella pneumoniae</i>in 24 h<i>in vitro</i>time–kill experiments

Abstract excerpt

OBJECTIVES: To investigate the activity of colistin alone or in double and triple combination with rifampicin and meropenem against NDM-1-producing Klebsiella pneumoniae. METHODS: Eight isolates of NDM-1-producing K. pneumoniae were exposed to clinically relevant antibiotic concentrations in 24 h time-kill experiments. Three colistin concentrations were used for two of the strains. Resistance development was...

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