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Pharmaco-nutritional strategies to increase nitric oxide signaling in Raynaud phenomenon (Nivose): a series of N-of-1 trials

2026-08-14

Abstract excerpt

<h4>Background: </h4> Treatment of Raynaud phenomenon(RP) with oral vasodilators(calcium channel block-ers and phosphodiesterase type 5 inhibitors) has shown moderate efficacy, may not benefit to all patients, and adverse effects often compromise long-term treatment. In addition, a large placebo effect may jeopardize the assessment of treatment benefits. Pharmaconutritional strategies aiming at increasing nitric o...

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Literature Corpus work
5c774466-ade3-5ab4-8828-52b1afd508fe
DOI
10.64898/2026.08.13.26360355
Open publication

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