Article

Safety and Exploratory Efficacy of Reduced β-Nicotinamide Mononucleotide Calcium Salt (NMNH-Ca) in Healthy Middle-Aged and Older Adults: A Randomized, Double-Blind, Placebo-Controlled Trial

2026-08-12

Abstract excerpt

Reduced nicotinamide mononucleotide (NMNH) is a reduced NAD⁺ precursor with reported NAD⁺-augmenting activity in preclinical models; however, controlled human data remain limited. This was a randomized, double-blind, placebo-controlled, parallel-group phase I trial evaluating oral NMNH-Ca in healthy adults aged 40-65 years. Eighty participants received placebo or NMNH-Ca 125, 250, or 500 mg once daily for 90 days....

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Literature Corpus work: f9a47efa-4745-516e-9abc-553d36f574d7
DOI: 10.64898/2026.08.11.26360226

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Safety and Exploratory Efficacy of Reduced β-Nicotinamide Mononucleotide Calcium Salt (NMNH-Ca) in Healthy Middle-Aged and Older Adults: A Randomized, Double-Blind, Placebo-Controlled TrialDOI 10.64898/2026.08.11.26360226Read

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