Article

(–)-Epicatechin alters reactive oxygen and nitrogen species production independent of mitochondrial respiration in human vascular endothelial cells

2021-10-28

Abstract excerpt

<h4>Introduction</h4> Vascular endothelial dysfunction is characterised by lowered nitric oxide (NO) bioavailability, which may be explained by increased production of reactive oxygen species (ROS), mitochondrial dysfunction and altered cell signalling. (-)-Epicatechin (EPI) has proven effective in the context of vascular endothelial dysfunction, but the underlying mechanisms associated with EPI’s effects remain...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 5c63e9ef-e31e-5a41-8d89-c99891771bbd
DOI: 10.1101/2021.10.25.465611

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

(–)-Epicatechin alters reactive oxygen and nitrogen species production independent of mitochondrial respiration in human vascular endothelial cellsDOI 10.1101/2021.10.25.465611Read

Cyanidin-3-O -glucoside counters the response to TNF-alpha of endothelial cells by activating Nrf2 pathwaySemantic proximity Read

Isorhamnetin Attenuates Isoproterenol-Induced Myocardial Injury by Reducing ENO1 in CardiomyocytesSemantic proximity Read

Exploring oxidative stress and endothelial dysfunction as a mechanism linking bisphenol S exposure to vascular disease in human umbilical vein endothelial cells and a mouse model of postnatal exposureSemantic proximity Read

Enhancement of mitochondrial biogenesis with polyphenols: combined effects of resveratrol and equol in human endothelial cellsSemantic proximity Read

A systems biology network analysis of nutri(epi)genomic changes in endothelial cells exposed to epicatechin metabolitesSemantic proximity Read

Nrf2 dysfunction and impaired cellular resilience to oxidative stressors in the aged vasculature: from increased cellular senescence to the pathogenesis of age-related vascular diseasesSemantic proximity Read

Ox-LDL induced endothelial progenitor cells oxidative stress via p38/Keap1/Nrf2 pathwaySemantic proximity Read

Adropin is involved in the protective effect of ellagic acid against high-glucose induced injury in human umbilical venous endothelial CellsSemantic proximity Read

<i>Nrf2</i>and Cardiovascular DefenseSemantic proximity Read

NADPH oxidase-derived reactive oxygen species in the regulation of endothelial phenotype.Semantic proximity Read

Preclinical Study on the Ameliorating Effect of L-Ascorbic Acid for the Oxidative Stress of Caused by Chronic Administration of Organic Nitrates in Cardiovascular DiseasesSemantic proximity Read

Reactive Oxygen Species are Essential for Placental Angiogenesis During Early GestationSemantic proximity Read