Article

Reduced CREB3L2 expression is associated with resistance to sorafenib and poor prognosis in ER-positive breast cancer

2016-10-03

Abstract excerpt

Sorafenib is a multikinase inhibitor that acts by inhibiting tumour growth and disrupting tumour microvasculature through anti-proliferative, anti-angiogenic, and pro-apoptotic effects. However, development of resistance to sorafenib often prevents its long-term efficacy. No validated biomarkers currently exist for appropriately selecting patients with cancer for sorafenib treatment. In the present study, we repor...

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Literature Corpus work: 5c1ebf85-b8aa-518d-9dc6-f5a36dfd255b
DOI: 10.1101/078949

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