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hInGeTox: A human-based in vitro platform to evaluate lentivirus contribution to genotoxicity

2024-01-11

Abstract excerpt

<title>Abstract</title> <p>Lentivirus vectors are effective for treatment of genetic disease and cancer, however, vector related insertional mutagenesis related genotoxicity is of concern and currently available safety models are not reliably predictive of safety in humans. We have developed <sup>h</sup>InGeTox as the first human <italic>in vitro</italic> platform that uses induced pluripotent stem cells and thei...

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Literature Corpus work
5bf6aba9-775f-52d4-9ffb-38834a5b969f
DOI
10.21203/rs.3.rs-3837253/v1
Open publication

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hInGeTox: A human-based in vitro platform to evaluate lentivirus contribution to genotoxicityDOI 10.21203/rs.3.rs-3837253/v1
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