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Wolfram syndrome 1 gene negatively regulates ER stress signaling in rodent and human cells

16 Feb 2010

Abstract excerpt

Wolfram syndrome is an autosomal-recessive disorder characterized by insulin-dependent diabetes mellitus, caused by nonautoimmune loss of beta cells, and neurological dysfunctions. We have previously shown that mutations in the Wolfram syndrome 1 (WFS1) gene cause Wolfram syndrome and that WFS1 has a protective function against ER stress. However, it remained to be determined how WFS1 mitigates ER stress. Here we...

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PMID: 20160352
DOI: 10.1172/jci39678

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