Article

Whole-Genome Deep Learning Predicts Chemotherapy Response in Colorectal Cancer

2025-07-31

Abstract excerpt

<title>Abstract</title> <p>Chemotherapy response in colorectal cancer (CRC) exhibits significant heterogeneity, with current clinical predictors failing to capture complex genomic determinants of resistance. We developed a hybrid deep learning framework integrating convolutional neural networks (CNNs) and bidirectional long short-term memory (BiLSTM) networks to analyze whole-genome somatic mutations, evolutionar...

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Literature Corpus work: 5befcc2e-5371-549e-a488-9bbf3d3931d9
DOI: 10.21203/rs.3.rs-7028381/v1

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