Interpretable multi-stage attention network to predict cancer subtype, microsatellite instability, TP53 mutation and TMB of endometrial and colorectal cancer.

doi:10.1016/j.compmedimag.2025.102499

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Article

Interpretable multi-stage attention network to predict cancer subtype, microsatellite instability, TP53 mutation and TMB of endometrial and colorectal cancer.

Computerized medical imaging and graphics : the official journal of the Computerized Medical Imaging Society - 1 Apr 2025

Wang Ching-Wei, Muzakky Hikam, Lee Yu-Ching, Chung Yu-Pang, Wang Yu-Chi, Yu Mu-Hsien, Wu Chia-Hua, Chao Tai-Kuang

Abstract excerpt

Mismatch repair deficiency (dMMR), also known as high-grade microsatellite instability (MSI-H), is a well-established biomarker for predicting the immunotherapy response in endometrial cancer (EC) and colorectal cancer (CRC). Tumor mutational burden (TMB) has also emerged as an important quantitative genomic biomarker for assessing the efficacy of immune checkpoint inhibitors. Although next-generation sequencing...

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PMID: 39947084
DOI: 10.1016/j.compmedimag.2025.102499

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TP53

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