PER1 enhances vascular normalization in hepatocellular carcinoma facilitating HIF-1α nuclear translocation

Abstract excerpt

<title>Abstract</title> <p><bold>Background: </bold>Blood vessels play a significant role in<bold> </bold>the pathogenesis of<bold> </bold>hepatocellular carcinoma (HCC).<bold> </bold>Emerging evidence suggests that dysregulation of the circadian clock gene, <italic>period 1</italic> (<italic>PER1</italic>), is closely associated with HCC tumorigenesis. However, it remains unknown whether <italic>PER1</italic> re...

Topics

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• Adipose Tissue and Metabolism
• Cancer, Hypoxia, and Metabolism
• Cancer, Lipids, and Metabolism
• Circadian rhythm and melatonin
• Epigenetics and DNA Methylation
• Kruppel-like factors research
• Mitochondrial Function and Pathology
• Renal cell carcinoma treatment

Identifiers and source

Literature Corpus work

5ba45f8e-179f-53a8-a8b0-6a3ece638b46

DOI

10.21203/rs.3.rs-4297202/v1