Article

Beyond 1100delC: Distinct CHEK2 Variants and Unique Cancer Phenotypes in Northeast Brazil

2025-10-10

Abstract excerpt

<title>Abstract</title> <p> The <italic>CHEK2</italic> gene confers a moderate risk for breast cancer, but existing knowledge is largely based on the European founder variant, 1100delC. This study aimed to characterize the distinct phenotypes associated with unique <italic>CHEK2</italic> variants in Brazilian families. In this cross-sectional study, 1055 patients meeting criteria for Hereditary Breast and Ov...

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Literature Corpus work: 5b66a120-bf6e-5061-bded-dadc4b3dc9ee
DOI: 10.21203/rs.3.rs-7653623/v1

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