Article

MGMT genomic rearrangements contribute to chemotherapy resistance in gliomas

2020-03-11

Abstract excerpt

Temozolomide (TMZ) is an oral alkylating agent used for the treatment of glioblastoma and is now becoming a chemotherapeutic option in patients diagnosed with high-risk low-grade gliomas. The O-6-methylguanine-DNA methyltransferase (MGMT) is responsible for the direct repair of the main TMZ-induced toxic DNA adduct, the O6-Methylguanine lesion. MGMT promoter hypermethylation is currently the only known biomarker...

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Literature Corpus work: 5b5bfbee-c587-5fbd-a8e2-df6c552489dc
DOI: 10.1101/2020.03.10.985226

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