Article

The Androgen Receptor: A Therapeutic Target in Desmoplastic Small Round Cell Sarcoma

2022-01-22

Abstract excerpt

<h4>ABSTRACT</h4> Desmoplastic small round cell tumor (DSRCT) is an aggressive, usually incurable sarcoma subtype that predominantly occurs in post-pubertal young males. Recent evidence suggests that the androgen receptor (AR) can promote tumor progression in DSRCTs. However, the mechanism of AR-induced oncogenic stimulation remains undetermined. Herein, we demonstrate that enzalutamide and AR-directed antisense...

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Literature Corpus work: 5ae74aee-2c89-58b6-b71a-6752672eb91a
DOI: 10.1101/2022.01.20.477146

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