Article

HOXA10-TWIST2 Antagonism Drives Partial Epithelial-to-Mesenchymal transition for Embryo Implantation

2025-01-10

Abstract excerpt

In mammalian reproduction, a significant proportion of embryos fail to implant despite a receptive uterus, suggesting that defects in epithelial remodelling at the embryo-uterine interface contribute to implantation failure. The molecular programs enabling such remodelling remain incompletely understood. Here, we identify a conserved transcriptional circuit involving HOXA10 and TWIST2 that regulates epithelial pla...

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Literature Corpus work: 5a584436-4bd6-50a4-b746-fd2173a83aac
DOI: 10.1101/2025.01.10.631632

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