Article

Identifying somatic structural rearrangements in leukaemia by tumour-only paired-end whole genome sequencing

2021-01-01

Abstract excerpt

Our understanding of the molecular pathogenesis of acute and chronic leukaemia has been greatly advanced by high-throughput next generation DNA sequencing. Nowadays, lymphoid, and myeloid malignancies are characterised by many somatically acquired genomic structural rearrangements including chromosomal translocations, inversions, large deletions or insertions, and internal tandem duplications, as well as chromosom...

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Literature Corpus work: 59be572c-ec27-553e-8925-214b1686b14d
DOI: 10.7488/era/1223

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