Article

Repression of the expression of proinflammatory genes by mitochondrial transcription factor A is linked to its alternative splicing regulation in human lung epithelial cells

2021-02-17

Abstract excerpt

<h4>Background: </h4> Mitochondrial transcription factor A (TFAM) is associated with a number of neurodegenerative diseases and also with asthma. TFAM deficiency-induced mitochondrial DNA stress primes the antiviral innate immune response in mouse embryonic fibroblasts. However, the role of TFAM in asthma related inflammation remains obscure. The purpose of this study was to investigate the regulatory mechanism of...

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Literature Corpus work: 5992a0c2-e6e1-5e9a-9db6-20b6bfbd94f2
DOI: 10.21203/rs.3.rs-204029/v1

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