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Soluble CTLA-4 raises the threshold for T-cell activation and modulates anti-tumour immunity

2023-06-07

Abstract excerpt

CTLA-4 is a crucial immune checkpoint receptor involved in the maintenance of immune homeostasis, tolerance, and tumour control. Antibodies targeting CTLA-4 have been promising treatment for numerous cancers, but the mechanistic basis of their anti-tumoral immune boosting effects are poorly understood. Although the ctla4 gene also encodes an alternatively-spliced soluble variant (sCTLA-4), preclinical/clinical ev...

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Literature Corpus work
58cb71b7-cc11-5547-ae64-e30e4c12536e
DOI
10.1101/2023.06.05.543731
Open publication

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Soluble CTLA-4 raises the threshold for T-cell activation and modulates anti-tumour immunityDOI 10.1101/2023.06.05.543731
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