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Regulation of an antibiotic resistance efflux pump by quorum sensing and a TetR-family repressor in <i>Chromobacterium subtsugae</i>

2023-09-03

Abstract excerpt

The soil bacterium Chromobacterium substugae uses a single LuxI-R-type quorum-sensing system, CviI-R, to regulate genes in a cell density-dependent manner. CviI synthesizes the signal N -hexanoyl-homoserine lactone (C6-HSL) and CviR is a C6-HSL-responsive cytoplasmic transcription regulator. C6-HSL-bound CviR activates dozens of genes, for example the cdeAB-oprM cluster coding for an efflux pump conferring anti...

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Literature Corpus work
5878258a-b196-5928-ba88-96c66cd5f5c3
DOI
10.1101/2023.09.02.556004
Open publication

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