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Hydroxychloroquine as Prophylactic Adjunct to BCG Vaccination in High-Risk Neonates: A Hypothesis for Triple Efficacy in Tuberculosis Prevention, BCG-Complication Mitigation, and SCID Safety

2026-03-18

Abstract excerpt

<h4>Background: </h4> BCG vaccination at birth remains the cornerstone of neonatal tuberculosis (TB) protection in high-burden countries. However, BCG induces severe, potentially fatal disseminated infection (BCGosis) in infants with Severe Combined Immunodeficiency (SCID). Saudi Arabia's 2019 policy delay of BCG to six months of age—intended to reduce BCGitis in SCID—leaves the vast immunocompetent neonatal popul...

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Literature Corpus work
57cab872-362f-5133-aa45-56a622fc49b1
DOI
10.20944/preprints202603.1422.v1
Open publication

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Hydroxychloroquine as Prophylactic Adjunct to BCG Vaccination in High-Risk Neonates: A Hypothesis for Triple Efficacy in Tuberculosis Prevention, BCG-Complication Mitigation, and SCID SafetyDOI 10.20944/preprints202603.1422.v1
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