Decrease in the Effectiveness of Bacille Calmette‐Guérin Vaccine against Pulmonary Tuberculosis: A Consequence of Increased Immune Suppression by Microbial Antioxidants, Not Overattenuation

Abstract excerpt

Mutations that arose in bacille Calmette-Guérin (BCG) daughter strains during decades of in vitro cultivation have long been suspected of reducing the efficacy of the BCG vaccine against pulmonary tuberculosis. Although concern was raised 6 decades ago that BCG had become overattenuated, preferential use of relatively virulent BCG vaccines has not restored efficacy. The recent discovery that as BCG evolved its...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Immune responses and vaccinations
• Share to Immunodeficiency and Autoimmune Disorders
• Share to Tuberculosis Research and Epidemiology