A systems-based approach to uterine fibroids identifies differential splicing associated with abnormal uterine bleeding

Abstract excerpt

<h4>ABSTRACT</h4> Uterine fibroids (UFs), benign tumours prevalent in up to 80% of women of reproductive age, are associated with significant morbidity, including abnormal uterine bleeding, pain and infertility. Despite identification of key genomic alterations in MED12 and HMGA2, the pathogenic mechanisms underlying UFs and heavy menstrual bleeding (HMB) remain poorly understood. To correlate systematically gene...

Topics

Open a Topic to create a Post that cites this publication.

• Endometriosis Research and Treatment
• Estrogens
• HMGA2 Protein
• Leiomyoma
• Mediator Complex
• Mutation
• Uterine Myomas and Treatments
• Uterine Neoplasms

Identifiers and source

Literature Corpus work

56d1b096-480b-52cc-a134-01bef20fcb05

DOI

10.1101/2024.02.06.578872