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Unexpected Long-Term Survival in Resected Pancreatic Ductal Adenocarcinoma Harboring KRAS G12D/SMAD4 Co-Mutation: A Case Report and Mini-Review

2026-05-28

Abstract excerpt

<h4>Background: </h4> Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy with a poor prognosis, even in resectable disease. Molecular alterations in the four major driver genes (KRAS, SMAD4, CDKN2A, and TP53) have been associated with disease progression and patient outcomes. However, reliable prognostic biomarkers remain limited, particularly in resected PDAC, where recurrence rates remain high....

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Literature Corpus work: 56cea0a9-4d5e-5919-9b21-bb7e529f8c1e
DOI: 10.20944/preprints202605.1987.v1

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