Article

Epigenetic, neuroplasticity, and adrenergic targets associated with major depression in immune cells

2025-07-24

Abstract excerpt

<title>Abstract</title> <p>Background Major depression (MD) has been linked to both neuroinflammation and impaired synaptic plasticity. Furthermore, epigenetic mechanisms involving certain histone deacetylases (HDACs) may initiate these changes. Specifically, altered expression of particular HDACs, including HDAC5, HDAC2, SIRT1, and SIRT2, has been associated with depressive-like behavior, suppressed levels of br...

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Literature Corpus work: 56b1527b-9294-5ee3-9bb4-44337fd6fa36
DOI: 10.21203/rs.3.rs-7178520/v1

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