Article

Proteomics Characteristics of Sciatic Nerves in Diabetic Peripheral Neuropathy, Key Gene DDI2 Identification and Comprehensive Therapeutic Strategy Exploration

2026-07-01

Abstract excerpt

<title>Abstract</title> <p>Diabetic peripheral neuropathy (DPN) affecting more than 50% of diabetic patients, manifests as progressive peripheral nerve damage. However, the exact molecular mechanisms are still elusive. This study employed proteomic profiling of sciatic nerves from db/db mice, identifying 80 differentially expressed proteins (DEPs) and demonstrating lipid metabolism imbalance, protein/amino acid h...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 55f42701-2e90-5d4a-b5d8-99fc34f4913e
DOI: 10.21203/rs.3.rs-10056680/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Proteomics Characteristics of Sciatic Nerves in Diabetic Peripheral Neuropathy, Key Gene DDI2 Identification and Comprehensive Therapeutic Strategy ExplorationDOI 10.21203/rs.3.rs-10056680/v1Read

Identification and validation of NAD+ metabolism-related biomarkers in patients with diabetic peripheral neuropathySemantic proximity Read

Identifying Autophagy-Related Genes contributing to Diabetes Peripheral NeuropathySemantic proximity Read

Three genes expressed in relation to lipid metabolism considered as potential biomarkers for the diagnosis and treatment of diabetic peripheral neuropathySemantic proximity Read

Three Genes Expressed in Relation to Lipid Metabolism Considered as Potential Biomarkers for the Diagnosis and Treatment of Diabetic NephropathySemantic proximity Read

Rapid degeneration of iPSC-derived motor neurons lacking Gdap1 engages a mitochondrial-sustained innate immune responseSemantic proximity Read

Lipin1 Alleviates Autophagy Disorder in Sciatic Nerve and Improves Diabetic Peripheral NeuropathySemantic proximity Read

Gene Expression Profiling Identifies Downregulation of the Neurotrophin-MAPK Signaling Pathway in Female Diabetic Peripheral Neuropathy PatientsSemantic proximity Read

Pyruvate kinase activates SARM1 to exacerbate axonal degeneration in diabetic peripheral neuropathySemantic proximity Read

Deciphering the molecular landscape of human peripheral nerves: implications for diabetic peripheral neuropathySemantic proximity Read

The identification of gene expression profiles associated with progression of human diabetic neuropathySemantic proximity Read

Integrated lipidomic and transcriptomic analyses identify altered nerve triglycerides in mouse models of prediabetes and type 2 diabetes.Semantic proximity Read

Macrophages protect against sensory axon degeneration in diabetic neuropathySemantic proximity Read