Article

Relationship between X chromosome mosaicism, neuroanatomy and cognitive performance in females

2026-02-10

Abstract excerpt

Females have two X chromosomes, one of which is inactivated early in development with specific regions and genes ‘escaping’ inactivation. Thus, X chromosome loss putatively results in decreased ‘dosage’ of X chromosome escapee and pseudoautosomal genes, impacting downstream pathways. Evidence from Turner syndrome indicates that X chromosome monosomy results in consistent neuroanatomical and cognitive phenotypes. H...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 5588843d-2488-500e-97d5-ae5453d76045
DOI: 10.64898/2026.02.07.704538

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Relationship between X chromosome mosaicism, neuroanatomy and cognitive performance in femalesDOI 10.64898/2026.02.07.704538Read

The Effects of X Chromosome Loss on Neuroanatomical and Cognitive Phenotypes During Adolescence: a Multi-modal Structural MRI and Diffusion Tensor Imaging Study.Semantic proximity Read

Neurocognitive variance and neurological underpinnings of the X and Y chromosomal variations.Semantic proximity Read

An extra X or Y chromosome: contrasting the cognitive and motor phenotypes in childhood in boys with 47,XYY syndrome or 47,XXY Klinefelter syndrome.Semantic proximity Read

Advances in research on the neurological and neuropsychiatric phenotype of Klinefelter syndrome.Semantic proximity Read

Revisiting the Neuropsychological and Clinical Profile of Mosaic Turner Syndrome With a Ring X Chromosome.Semantic proximity Read

Distinctive patterns of memory function in subgroups of females with Turner syndrome: evidence for imprinted loci on the X-chromosome affecting neurodevelopment.Semantic proximity Read

The contribution of Xp22.31 gene dosage to Turner and Klinefelter syndromes and sex-biased phenotypes.Semantic proximity Read

X- vs. Y-chromosome dosage effects on human cognition: a deep phenotypic comparison of 47,XXY and 47,XYY syndromes.Semantic proximity Read

Effect of sex chromosome number variation on attention‐deficit/hyperactivity disorder symptoms, executive function, and processing speedSemantic proximity Read

The maternal X chromosome impairs cognition and accelerates brain aging through epigenetic modulation in female miceSemantic proximity Read

X-monosomy effects on visuospatial attention in mice: a candidate gene and implications for Turner syndrome and attention deficit hyperactivity disorder.Semantic proximity Read

Effects of sex chromosome aneuploidies on brain development: evidence from neuroimaging studies.Semantic proximity Read