Article

Deubiquitinating enzyme USP48 mediates pyroptosis and meliorates immune evasion in tumors by stabilizing GSDME expression

2021-11-11

Abstract excerpt

<title>Abstract</title> <p>Pyroptosis is a kind of programmed cell death, which is characterized by the activation of inflammatory caspase and the cleavage of gasdermin proteins. It is widely involved in the occurrence and development of tumors. Studies have shown that ubiquitin related proteins play a key regulatory role in many biological processes. However, the role and molecular mechanism of ubiquitin-related...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 5530fc5e-db5e-5c0f-8a70-1c3129dd07e7
DOI: 10.21203/rs.3.rs-1046804/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Deubiquitinating enzyme USP48 mediates pyroptosis and meliorates immune evasion in tumors by stabilizing GSDME expressionDOI 10.21203/rs.3.rs-1046804/v1Read

Pyroptosis, inflammasome, and gasdermins in tumor immunitySemantic proximity Read

Synthetic lethality of combined ULK1 defection and p53 restoration induce pyroptosis by directly upregulating GSDME transcription and cleavage activation through ROS/NLRP3 signalingSemantic proximity Read

Gasdermin E: A Prospective Target for Therapy of DiseasesSemantic proximity Read

Biological Functions of Gasdermins in Cancer: From Molecular Mechanisms to Therapeutic PotentialSemantic proximity Read

Deubiquitinating enzymes: Key regulators of ferroptosis and pyroptosis and novel targets for cancer interventionSemantic proximity Read

Ubiquitin-specific peptidase 10, a deubiquitinating enzyme: Assessing its role in tumor prognosis and immune responseSemantic proximity Read

Deubiquitylating Enzymes in Cancer and ImmunitySemantic proximity Read

Integrative and Comprehensive Pan-cancer Analysis of Ubiquitin Specific Peptidase 11 (USP11) As a Prognostic and Immunological BiomarkerSemantic proximity Read

Cellular functions, molecular signalings and therapeutic applications: Translational potential of deubiquitylating enzyme USP9X as a drug target in cancer treatmentSemantic proximity Read

USP22 deficiency in melanoma mediates resistance to T cells through IFNγ-JAK1-STAT1 signal axisSemantic proximity Read

Ubiquitin-specific protease 28: the decipherment of its dual roles in cancer developmentSemantic proximity Read

Targeting pyroptosis for cancer immunotherapy: mechanistic insights and clinical perspectivesSemantic proximity Read