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Metagenomic polymorphic toxin effector and immunity profiling predicts microbiome development and disease-related dysbiosis

2025-07-08

Abstract excerpt

Bacteria use antagonistic interbacterial weapons such as polymorphic toxin secretion systems (TSS) to compete for niches in the human gut microbiome. We developed a bioinformatic marker gene approach (PolyProf) to quantify TSS including ∼200 effector and immunity genes and applied it to ∼15,000 publicly available human metagenomes. PolyProf alpha and beta diversity readily distinguished 12 different human disease...

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Identifiers and source

Literature Corpus work
54fb0109-d030-518c-82ca-11fec60c47b3
DOI
10.1101/2025.07.08.662037
Open publication

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Metagenomic polymorphic toxin effector and immunity profiling predicts microbiome development and disease-related dysbiosisDOI 10.1101/2025.07.08.662037
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