Article

Acceptability of advanced Controlled Human Infection Models; the case of a pneumococcal challenge in people living with HIV and mycobacterial challenge with Bacillus Calmette Guerin in Malawi

2026-03-23

Abstract excerpt

<h4>Background</h4> Controlled Human Infection Models (CHIM) in which volunteers are experimentally exposed to pathogens are used to study pathogenesis and down select among treatment and vaccine candidates. Scientifically, CHIM studies are best conducted among at-risk populations in which the infection is endemic, and who are likely to benefit from new interventions tested. Ethically, the perspectives of these c...

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Literature Corpus work: 91d5f10b-042c-5037-ae3d-9f40a2755f1a
DOI: 10.64898/2026.03.19.26348855

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