Article

An endothelial SOX18-mevalonate pathway axis enables repurposing of statins for infantile hemangioma

2024-01-31

Abstract excerpt

<h4>ABSTRACT</h4> Infantile hemangioma (IH) is the most common tumor in children and a paradigm for pathological vasculogenesis, angiogenesis and regression. Propranolol is the mainstay of treatment for IH. It inhibits hemangioma vessel formation via a β-adrenergic receptor independent off-target effect of its R(+) enantiomer on the endothelial specific transcription factor sex-determining region Y (SRY) box tran...

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Literature Corpus work: 54451af0-41e1-5320-87fc-06e4b02bbc30
DOI: 10.1101/2024.01.29.577829

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