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Article

CDIN1-Codanin-1 complex defective in congenital dyserythropoietic anaemia type I is an RNA nuclease.

Nature communications - 2 Jul 2026

Brolih Sanja, Ali Hafiz Saqib, Scott Caroline, Olijnik Aude-Anais, Aitkenhead Hazel, Moir-Meyer Gemma, Gavard Angeline E, Yosaatmadja Yuliana, Higgs Douglas R, Buckle Veronica, Roy Noemi, Gileadi Opher, Newman Joseph A, Duarte Fernanda, Babbs Christian, McHugh Peter J

Abstract excerpt

Congenital Dyserythropoietic Anaemia type I (CDA-I) is a rare inherited disorder of erythropoiesis, in which erythroid cells display a unique nuclear phenotype referred to as 'spongy' heterochromatin. The molecular basis of CDA-I remains unknown, with most cases of CDA-I caused by mutations in CDAN1, encoding Codanin-1, or CDIN1, encoding for Codanin-1-interacting nuclease 1 (CDIN1). To date, very little is known...

Topics

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Anemia, Dyserythropoietic, Congenital
CDA gene
Glycoproteins
Molecular Dynamics Simulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Nuclear Proteins

Protein Binding

Source

Open in PubMed Open full text

Identifiers

PMID: 42393042
DOI: 10.1038/s41467-026-74766-7
PMCID: PMC13463051

Genes

CDIN1
CDA
CDAN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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CDIN1-Codanin-1 complex defective in congenital dyserythropoietic anaemia type I is an RNA nuclease.PMID 42393042Read ↗

Anemia-associated mutations disrupt the CDIN1-Codanin1 complex in inherited congenital dyserythropoietic anemia I (CDA-I) disease.Semantic proximity Read ↗

Inherited CDA-I disease: anemia-associated mutations disrupt CDIN1-Codanin1 complexSemantic proximity Read ↗

A complex comprising C15ORF41 and Codanin-1: the products of two genes mutated in congenital dyserythropoietic anaemia type I (CDA-I).Semantic proximity Read ↗

Genetic and functional insights into CDA-I prevalence and pathogenesis.Semantic proximity Read ↗

Characterization of the interactions between Codanin-1 and C15Orf41, two proteins implicated in Congenital dyserythropoietic anemia type I diseaseSemantic proximity Read ↗

Homozygous mutations in a predicted endonuclease are a novel cause of congenital dyserythropoietic anemia type ISemantic proximity Read ↗

Characterization of the interactions between Codanin-1 and C15Orf41, two proteins implicated in congenital dyserythropoietic anemia type I disease.Semantic proximity Read ↗

Congenital dyserythropoietic anemia type I is caused by mutations in codanin-1.Semantic proximity Read ↗

Mechanism of ASF1 Inhibition by CDAN1Semantic proximity Read ↗

Characterization of Two Cases of Congenital Dyserythropoietic Anemia Type I Shed Light on the Uncharacterized C15orf41 ProteinSemantic proximity Read ↗

Recapitulation of erythropoiesis in congenital dyserythropoietic anemia type I (CDA-I) identifies defects in differentiation and nucleolar abnormalitiesSemantic proximity Read ↗

Codanin-1 mutations in congenital dyserythropoietic anemia type 1 affect HP1{alpha} localization in erythroblasts.Semantic proximity Read ↗

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