Article
A complex comprising C15ORF41 and Codanin-1: the products of two genes mutated in congenital dyserythropoietic anaemia type I (CDA-I).
The Biochemical journal - 29 May 2020
Shroff Maithili, Knebel Axel, Toth Rachel, Rouse John
Abstract excerpt
Congenital dyserythropoietic anaemia (CDA) type I is a rare blood disorder characterised by moderate to severe macrocytic anaemia and hepatomegaly, with spongy heterochromatin and inter-nuclear bridges seen in bone marrow erythroblasts. The vast majority of cases of CDA type I are caused by mutations in the CDAN1 gene. The product of CDAN1 is Codanin-1, which interacts the histone chaperone ASF1 in the cytoplasm....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.