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Article

Codanin-1 mutations in congenital dyserythropoietic anemia type 1 affect HP1{alpha} localization in erythroblasts.

Blood - 23 Jun 2011

Renella Raffaele, Roberts Nigel A, Brown Jill M, De Gobbi Marco, Bird Louise E, Hassanali Tasneem, Sharpe Jacqueline A, Sloane-Stanley Jacqueline, Ferguson David J P, Cordell Jacqueline, Buckle Veronica J, Higgs Douglas R, Wood William G

Abstract excerpt

Congenital dyserythropoietic anemia type 1 (CDA-1), a rare inborn anemia characterized by abnormal chromatin ultrastructure in erythroblasts, is caused by abnormalities in codanin-1, a highly conserved protein of unknown function. We have produced 3 monoclonal antibodies to codanin-1 that demonstrate its distribution in both nucleus and cytoplasm by immunofluorescence and allow quantitative measurements of...

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Share to Anemia, Dyserythropoietic, Congenital
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Chromobox Protein Homolog 5

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Source

Identifiers

PMID: 21364188
DOI: 10.1182/blood-2010-09-308478

Genes

CDA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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Codanin-1 mutations in congenital dyserythropoietic anemia type 1 affect HP1{alpha} localization in erythroblasts.PMID 21364188Read ↗

Anemia-associated mutations disrupt the CDIN1-Codanin1 complex in inherited congenital dyserythropoietic anemia I (CDA-I) disease.Semantic proximity Read ↗

Inherited CDA-I disease: anemia-associated mutations disrupt CDIN1-Codanin1 complexSemantic proximity Read ↗

Codanin-1, the protein encoded by the gene mutated in congenital dyserythropoietic anemia type I (CDAN1), is cell cycle-regulated.Semantic proximity Read ↗

Codanin-1 mutations engineered in human erythroid cells demonstrate role of CDAN1 in terminal erythroid maturation.Semantic proximity Read ↗

Congenital dyserythropoietic anemia type I is caused by mutations in codanin-1.Semantic proximity Read ↗

Genetic and functional insights into CDA-I prevalence and pathogenesis.Semantic proximity Read ↗

CDIN1-Codanin-1 complex defective in congenital dyserythropoietic anaemia type I is an RNA nuclease.Semantic proximity Read ↗

A complex comprising C15ORF41 and Codanin-1: the products of two genes mutated in congenital dyserythropoietic anaemia type I (CDA-I).Semantic proximity Read ↗

Characterization of the interactions between Codanin-1 and C15Orf41, two proteins implicated in Congenital dyserythropoietic anemia type I diseaseSemantic proximity Read ↗

Recapitulation of erythropoiesis in congenital dyserythropoietic anemia type I (CDA-I) identifies defects in differentiation and nucleolar abnormalitiesSemantic proximity Read ↗

Mechanism of ASF1 Inhibition by CDAN1Semantic proximity Read ↗

Characterization of the interactions between Codanin-1 and C15Orf41, two proteins implicated in congenital dyserythropoietic anemia type I disease.Semantic proximity Read ↗

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