Article

The CoREST Repressor Complex Mediates Phenotype Switching and Therapy Resistance in Melanoma

2020-10-02

Abstract excerpt

Virtually all patients with BRAF-mutant melanoma develop resistance to MAPK inhibitors largely through non-mutational events 1,2 . Although the epigenetic landscape has been shown to be altered in therapy-resistant melanomas and other cancers 3,4 , a specific targetable epigenetic mechanism regulating treatment resistance has not been validated to date. Here we evaluate the CoREST repressor complex and the novel...

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Literature Corpus work: 534458dc-119c-53c0-9fa0-d042e0008bde
DOI: 10.1101/2020.09.30.320580

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