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Molecular characterization of gut microbiota in high‑lipid diet‑induced hyperlipidemic rats treated with simvastatin

26 Feb 2020

Abstract excerpt

Hyperlipidemia is a major risk factor for cardiovascular diseases. Simvastatin (SV), a cholesterol‑lowering agent, has been widely used in the treatment of hyperlipidemia. Gut microbiota is known to influence drug response, including that to statins. However, the effect of SV on the gut microbiota of hyperlipidemic rats is not fully understood. To investigate the influence of SV on gut microbiota in...

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PMID: 32323749
DOI: 10.3892/ijmm.2020.4516

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