Orthogonal Drug Pooling Enhances Phenotype-based Discovery of Ocular Anti-angiogenic Drugs in Zebrafish Larvae

Abstract excerpt

Unbiased screening of large randomized chemical libraries in vivo is a powerful tool to find new drugs and targets. However, forward chemical screens in zebrafish can be time consuming and usually >99% of test compounds have no significant effect on the desired phenotype. Here, we sought to find bioactive drugs more efficiently and to comply with the 3R principles of replacement, reduction and refinement of anima...

Topics

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• Angiogenesis Inhibitors
• Drug Discovery
• Drug Evaluation, Preclinical
• Embryo, Nonmammalian
• Larva
• Phenotype
• Small Molecule Libraries
• Zebrafish

Identifiers and source

Literature Corpus work

52ce2376-46c7-534a-9ad2-c8d7f0d81784

DOI

10.1101/559781