Article

Botulinum Toxin Resistance: A Comprehensive Systematic Review of Mechanisms, Risk Factors, Diagnosis, and Management Strategies

2025-06-05

Abstract excerpt

<h4>Background: </h4> Botulinum neurotoxin (BoNT) has transformed the treatment of neurological, pain, and aesthetic conditions by inducing temporary muscle paralysis through inhibition of acetylcholine release at the neuromuscular junction. However, treatment failure or resistance poses a significant clinical challenge. Resistance manifests as primary non-response (innate insensitivity) or secondary non-response...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 52bcfe85-07d6-5e5c-9744-eb3a5ff4a164
DOI: 10.20944/preprints202506.0418.v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Botulinum Toxin Resistance: A Comprehensive Systematic Review of Mechanisms, Risk Factors, Diagnosis, and Management StrategiesDOI 10.20944/preprints202506.0418.v1Read

Challenges in searching for therapeutics against Botulinum NeurotoxinsSemantic proximity Read

Embracing the Versatility of Botulinum Neurotoxins in Conventional and New Therapeutic ApplicationsSemantic proximity Read

Therapeutic Applications of Botulinum Neurotoxins in Veterinary MedicineSemantic proximity Read

Botulinum Toxin: A Comprehensive Review of Its Molecular Architecture and Mechanistic ActionSemantic proximity Read

Clinical characterization of 145 cases of botulinum toxin injection-induced cosmetic poisoningSemantic proximity Read

Light Chain Diversity among the Botulinum NeurotoxinsSemantic proximity Read

Botulinum Toxin Type A: Efficacy in the management of Lower Limb Spasticity in Children with Genetic DisordersSemantic proximity Read

Structural Insights into Rational Design of Single-Domain Antibody-Based Antitoxins against Botulinum NeurotoxinsSemantic proximity Read

A Comprehensive Structural Analysis of Clostridium botulinum Neurotoxin A Cell-Binding Domain from Different SubtypesSemantic proximity Read

Probing the structure and function of the protease domain of botulinum neurotoxins using single-domain antibodiesSemantic proximity Read

Sequence variation within botulinum neurotoxin serotypes impacts antibody binding and neutralization.Semantic proximity Read

Novel <i>Clostridium botulinum</i> Toxin Gene Arrangement with Subtype A5 and Partial Subtype B3 Botulinum Neurotoxin GenesSemantic proximity Read