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Biallelic variants in ZFP36L2 cause female infertility characterised by recurrent preimplantation embryo arrest

5 Oct 2021

Abstract excerpt

BACKGROUND: Recurrent preimplantation embryo developmental arrest (RPEA) is the most common cause of assisted reproductive technology treatment failure associated with identified genetic abnormalities. Variants in known maternal genes can only account for 20%-30% of these cases. The underlying genetic causes for the other affected individuals remain unknown. METHODS: Whole exome sequencing was performed for 100...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 34611029
DOI: 10.1136/jmedgenet-2021-107933

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