Back to search

Article

Beyond Volume: Unraveling the Genetics of Human Brain Geometry

2024-06-25

Abstract excerpt

Brain geometry impacts brain function. A quantitative encoding of form is provided by the Laplace-Beltrami operator’s spectrum of eigenvalues (LBS). We examined LBS genetics of 22 subcortical brain structures including cerebellum in 19,862 healthy White-British UK Biobank participants by multivariate GWAS (MOSTest) on the first 49 eigenvalues each. Controlling for surface and volume, we identified 80 unique varian...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
528fc476-b306-5064-a261-8ca8a34871a9
DOI
10.1101/2024.06.25.24309376
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Beyond Volume: Unraveling the Genetics of Human Brain GeometryDOI 10.1101/2024.06.25.24309376
Multidimensional heritability analysis of neuroanatomical shape.Semantic proximity
Multidimensional Heritability Analysis of Neuroanatomical ShapeSemantic proximity
Genetic influences on the shape of brain ventricular and subcortical structuresSemantic proximity
Distributed Genetic Effects on Human Brain Structure Emerge Across Multiple Spatial ScalesSemantic proximity
Mapping the genetic architecture of cortical morphology through neuroimaging: progress and perspectives.Semantic proximity
Sex-Dependent Age Trajectories of Subcortical Brain Structures: Analysis of Large-Scale Percentile Models and Shape MorphometrySemantic proximity
Genetics and brain morphology.Semantic proximity
The genetic architecture of the human cerebral cortexSemantic proximity
Genomic architecture of human neuroanatomical diversity.Semantic proximity
Genomic Structural Equation Modeling Reveals Latent Phenotypes in the Human Cortex with Distinct Genetic ArchitectureSemantic proximity
The genetic architecture of human cortical foldingSemantic proximity
Genomic architecture of human neuroanatomical diversitySemantic proximity
Select a neighboring publication to make it the new centre.