Article

A novel pan class-I glucose transporter inhibitor DRB18 exhibits synergistic effects with paclitaxel <i>in vitro</i> and <i>in vivo</i> against human non-small cell lung cancer

2024-12-17

Abstract excerpt

<h4>Purpose</h4> Cancer cells depend on glucose for biomass synthesis, cell proliferation, and drug resistance. Glucose transporter (GLUT) transcripts as well as proteins are upregulated in human lungs and other cancers and are negatively correlated with patient survival, particularly GLUT1 and GLUT3. Thus, inhibiting GLUT function has been an attractive anticancer strategy. We previously characterized WZB117 and...

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Literature Corpus work: 526e63db-e2d2-5dde-96fc-66d61194277d
DOI: 10.1101/2024.12.15.628558

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