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Article

Interactions between Sox10 and EdnrB modulate penetrance and severity of aganglionosis in the Sox10Dom mouse model of Hirschsprung disease.

Human molecular genetics - 1 Oct 2004

Cantrell V Ashley, Owens Sarah E, Chandler Ronald L, Airey David C, Bradley Kevin M, Smith Jeffrey R, Southard-Smith E Michelle

Abstract excerpt

Cumulative evidence suggests that Hirschsprung disease (HSCR) is the consequence of multiple gene interactions that modulate the ability of enteric neural crest (NC) cells to populate the developing gut. One of the essential genes for this process is the NC transcription factor Sox10. Sox10Dom mice on a mixed genetic background show variation in penetrance and expressivity of enteric aganglionosis that are...

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Source

Identifiers

PMID: 15294878
DOI: 10.1093/hmg/ddh243

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Interactions between Sox10 and EdnrB modulate penetrance and severity of aganglionosis in the Sox10Dom mouse model of Hirschsprung disease.PMID 15294878Read ↗

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