Article
The roles of senescence and telomere shortening in cardiovascular disease.
Nature reviews. Cardiology - 1 May 2013
Fyhrquist Frej, Saijonmaa Outi, Strandberg Timo
Abstract excerpt
Cellular senescence, defined as arrest during the cell cycle (G₀), is involved in the complex process of the biological ageing of tissues, organs, and organisms. Senescence is driven by many factors including oxidative stress, the DNA damage and repair response, inflammation, mitogenic signals, and telomere shortening. Telomeres are shortened by each cell division until a critical length is reached and...
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